Publications
1. Natalia Soriano-Sarabia, PhD; Alejandro Vallejo, PhD; Reposo Ramírez-Lorca, hD; María del Mar Rodríguez; Ana Salinas; Ildefonso Pulido; María Eugenia Sáez, PhD; ManuelLeal, MD, PhD. Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load and clinical progression. Journal of AIDS
2. Gayán J, González-Perez A, Bermudo F, Sáez ME, Royo JL, Quintas A, Galan JJ, Morón FJ, Ramirez-Lorca R, Real LM, Ruiz A. A Method for Detecting Epistasis in Genome-Wide Studies Using Case-Control Multi-Locus Association Analysis. BMC genomics.
3. Sáez ME, González-Sánchez JL, Ramírez-Lorca R, Martínez-Larrad MT, Zabena C, Martínez-Calatrava MJ, González A, Morón FJ, Ruiz, A, Serrano-Ríos M. The CAPN10 Gene is associated to insulin resistance phenotypes in the spanish population. Plos One.
4. Hidalgo-Pascual M, Saez ME, Martinez-Tello FJ, Moron FJ, Ferrero Herrero E, Labalde Martinez M, Rigopoulou D Ballestin Carcavilla C, Ruiz A, Royo JL, Ramirez-Lorca R. Allelic Imbalance analysis of EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma. Journal of Endocrine Investigation.
5. Carretero R, Romero JM, Ruiz-Cabello F, Maleno I, Rodriguez F, Camacho FM, Real LM, Garrido F, Cabrera T. Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy. Immunogenetics. 2008 Aug;60(8):439-47. Epub 2008 Jun 11.
6. Sáez ME, Grilo A, Morón Fj, Manzano L, González-Pérez A, Serrano-Hernando A, Ruiz A,Ramírez-Lorca R, Serrano-Ríos M. The peroxisome proliferator-activated receptor delta gene is associated with obesity and interacts with the calpain 5 gene to modulate the phenotype. Cardiovascular Diabetology 2008, 7:23
7. Gayán J, Brocklebank D, Andresen JM, Alkorta-Aranburu G; US-Venezuela Collaborative Research Group, Zameel Cader M, Roberts SA, Cherny SS, Wexler NS, Cardon LR, Housman DE. Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. Genet Epidemiol. 2008 Jul;32(5):445-53.
8. Aptsiauri N, Carretero R, Garcia-Lora A, Real LM, Cabrera T, Garrido F. Regressing and progressing metastatic lesions: resistance to immunotherapy is predetermined by irreversible HLA class I antigen alterations. Cancer Immunol Immunother. 2008 May 20. [Epub ahead of print]
9. Hidalgo M, Galan JJ, Sáez C, Ferrero E, Castilla C, Ramirez-Lorca R, Pelaez P, Ruiz A, Japón MA, Royo JL. Methylation alterations are not a major cause of PTTG1 misregulation. BMC Cancer. 2008 Apr 21;8:110.
10. Mendoza N,Morón FJ, Quereda F, Vázquez F, Rivero MC, Martínez-Astorquiza T, Real LM, Sánchez-Borrego R, González-Pérez A, Ruiz A. A Digenic Combination of Polymorphisms Within ESR1 and ESR2 Genes Are Associated With Age at Menarche in the Spanish Population. Reproductive Sciences 2008 Apr;15(3):305-11
11. Galan JJ, Buch B, Pedrinaci S, Jimenez-Gamiz P, Gonzalez A, Serrano-Rios M, SalinasA, Rivero MC, Real LM, Royo JL, Ruiz A. Identification of a 2244 base-pair interstitial deletion within the human ESR1 gene in the Spanish Population. J Med Genet. 2008 Jul;45(7):420-4. Epub 2008 Apr 18.
12. Gonzalez-Mancha R., Galan JJ., Crespo C., Iglesias-Pérez L.,González Pérez A., Morón FJ., Moreno Nogueira JA., Real LM., Hidalgo Pascual M., Ruiz A., Royo JL. Analysis of the ERalpha germline Pvull marker in breast cancer risk. Medical Science Monitor. 2008.
13. Hidalgo-Pascual M., Galan JJ., Chaves-Conde M., Ramírez-Armengol JA., Moreno C., Calvo E., Pelaez P., Crespo C., Ruiz A., Royo JL. Analysis of CXCL12 3'UTR G> A polymorphism in colorectal cancer. Oncology Rep 2007. In Press
14. Ramirez-Lorca R., Grilo A., Martinez-Larraz MT., Manzano L., Serrano-Hernando FJ., Morn FJ., Perez-González V., González-Sánchez JL., Fresneda J., Fernández-Parrilla R., Moux G., Molero E., Sánchez E., Martínez-Calatrava MJ:, Saban-Ruiz J., Ruiz A., Saez ME., Serrano-Rios M. Sex and Body Mass Index Specific Regulation of Blood Pressure by CYP19A1 Gene Variants. Hypertension. 2007 Nov;50(5):884-90. PMID: 17893373
15. González A., Ramírez-Lorca R. Calatayud C., Mendoza N., Ruiz A., Saez M.E., Moron F.J. Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome. Fertil Steril. 2007 Sep 28; PMID: 17905236
16. Moron F.J., Galan J.J., Ruiz A. Controlled ovarian hyperstimulation pharmacogenetics: a simplified model to genetically dissect estrogen-related diseases. Pharmacogenomics. 2007 Jul;8(7):775-85. PMID: 17638514 PMID: 17638514
17. Royo J.L., Hidalgo M., Ruiz A. Pyrosequencing protocol using a universal biotinylated primer for mutation detection and SNP genotyping. Nat Protoc. 2007;2(7):1734-9. PMID: 17641638
18. Carmen Poves Frances, Manuel Chaves Conde, Maria Eugenia Saez, Servando Fernandez Diez, Concha Moreno Rey, Juan Andres Ramirez-Armengol, Manuel Hidalgo Pascual, Antonio Gonzalez-Perez, Pablo Pelaez Torres, Luis Miguel Real, Manuel Serrano-Rios, José Luis Garca Lopez, Agustin Ruiz, Jose Luis Royo. Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility. J Gastroenterol Hepatol. 2007 Jun 7; PMID: 17559371
19. Moron FJ, Mendoza N, Quereda F, Vazquez F, Ramirez-Lorca R, Velasco J, Gallo JL, Salinas A, Martinez-Astorquiza T, Sanchez-Borrego R, Saez ME, Ruiz A. "Pyrosequencing Technology for Automated Detection of the BMP15 A180T Variant in Spanish Postmenopausal Women, " Clin Chem. 2007 Jun; 53: 1162-64. No abstract available
20. Esteban F, Royo JL, Gonzalez-Moles MA, Gonzalez-Perez A, Redondo M, Moreno-Luna R, Rodriguez-Sola M, Gonzalez A, Real LM, Ruiz A, Ramirez-Lorca R. CAPN10 alleles modify laryngeal cancer risk in the Spanish population. Eur J Surg Oncol. 2007 Mar 21; PMID: 17382509
21.Galan JJ, Guarducci E, Nuti F, Gonzalez A, Ruiz M, Ruiz A, Krausz C. Molecular analysis of estrogen receptor alpha gene AGATA haplotype and SNP12 in European populations: potential protective effect for cryptorchidism and lack of association with male infertility. Hum Reprod. 2007 Feb;22(2):444-9. PMID: 17099213
22. Saez M.E., Martinez-Larraz M.T., Ramirez-Lorca R., González-Sánchez JL, Zabena C., Martínez-Calatrava M.J., González A., Morón F.J., Ruiz A., Serrano-Rios M. Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. BMC medical genetics 2007. PMID: 17227582
23. Galan JJ, De Felici M, Buch B, Rivero MC, Segura A, Royo JL, Cruz N, Real LM, Ruiz A. Association of genetic markers within the KIT and KITLG genes with human male infertility. Hum Reprod. 2006 Dec;21(12):3185-92. PMID: 16905672
24. Royo JL, Moreno-Nogueira JA, Galan JJ, Gonzalez-Martin A, Ruiz A, Gonzalez-Mancha R, Real LM. Lack of Association Between NOS3 Glu298Asp and Breast Cancer Risk: a Case-ontrol Study. Breast Cancer Res Treat. 2006 Dec;100(3):331-3. PMID: 16807677
25. Gonzalez-Sanchez JL, Martinez-Larrad MT, Saez ME, Zabena C, Martinez-Calatrava MJ, Serrano-Rios M. Endothelial nitric oxide synthase haplotypes are associated with features of metabolic syndrome. Clin Chem. 2007 Jan;53(1):91-7. PMID: 17110473
26. Ortiz P., Vanaclocha F., Lopez-Bran E., Esquivias J.I., Lopez Estebaranz J.L., Martin-Gonzalez M., Arrue I., Garcia-Romero D., Ochoa C., Gonzalez-Perez A., Ruiz A., Real L.M: Genetic analysis of the GRM1 gene in human melanoma susceptibility. European Journal of human Genetics 2007
PMID: 17609672
27. Saez ME, Ramirez-Lorca R, Moron FJ, Ruiz A. The therapeutic potential of the calpain family: new aspects. Drug Discov Today. 2006 Oct;11(19-20):917-23. Review. PMID: 16997142
28. Cabrera T, Lara E, Romero JM, Maleno I, Real LM, Ruiz-Cabello F, Valero P, Camacho FM, Garrido F. HLA class I expression in metastatic melanoma correlates with tumor development during autologous vaccination. Cancer Immunol Immunother. 2006 Sep 8 PMID: 16960691
29. Conde MC, Ramirez-Lorca R, Lopez-Jamar JM, Molero E, Ramirez-Armengol JA, Moreno Nogueira JA, Pascual MH, Ruiz A, Martin-Cordova CG, Real LM, Royo JL. Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer. Oncol Rep. 2006 Aug;16(2):353-9. PMID: 16820915
30. Moron FJ, de Castro F, Royo JL, Montoro L, Mira E, Saez ME, Real LM, Gonzalez A, Manes S, Ruiz A. Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). Pharmacogenet Genomics. 2006 Jul;16(7):485-95. PMID: 16788381
31. Moron FJ, Mendoza N, Vazquez F, Molero E, Quereda F, Salinas A, Fontes J, Martinez-Astorquiza T, Sanchez-Borrego R, Ruiz A. Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis. Bone. 2006 Jul;39(1):213-21. PMID: 16530497
32. Grilo A, Fernandez ML, Beltran M, Ramirez-Lorca R, Gonzalez MA, Royo JL, Gutierrez-Tous R, Moron FJ, Couto C, Serrano-Rios M, Saez ME, Ruiz A, Real LM. Genetic analysis of CAV1 gene in hypertension and metabolic syndrome. Thromb Haemost. 2006 Apr;95(4):696-701. PMID: 16601841
33. Royo JL, Pascual MH, Salinas A, Tello FJ, Rivero Mdel C, Herrero EF, Real LM, Ruiz A. Pyrosequencing protocol requiring a unique biotinylated primer. Clin Chem Lab Med. 2006;44(4):435-41. PMID: 16599838
34. Pascual MH, Royo JL, Martinez-Tello FJ, Crespo C, Salinas A, Herrero EF, Lopez-Garcia M, Real LM, Ruiz A, Ramirez-Lorca R. Exploring allelic imbalance within paraffin-embedded tumor biopsies using pyrosequencing technology. Clin Chem Lab Med. 2006;44(9):1076-81. PMID: 16958598
35. Gonzalez A, Saez ME, Aragon MJ, Galan JJ, Vettori P, Molina L, Rubio C, Real LM, Ruiz A, Ramirez-Lorca R. Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. Hum Reprod. 2006 Apr;21(4):943-51. PMID: 16396936
36. Mendoza N, Moron FJ, Vazquez F, Quereda F, Saez ME, Martinez-Astorquiza T, Gonzalez-Perez A, Sanchez-Borrego R, Ruiz A. Weighting the effect of CYP19A gene in bone mineral density of postmenopausal women. Bone. 2006 Jun;38(6):951-3; author reply 953.No abstract available. PMID: 16338189
37. Galan JJ, Buch B, Cruz N, Segura A, Moron FJ, Bassas L, Martinez-Pineiro L, Real LM, Ruiz A. Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology. Fertil Steril. 2005 Oct;84(4):910-8. PMID: 16213843
38. de Castro F, Moron FJ, Montoro L, Real LM, Ruiz A. Pharmacogenetics of controlled ovarian hyperstimulation. Pharmacogenomics. 2005 Sep;6(6):629-37. Review. PMID: 16143002
39. Caballero V, Ruiz R, Sainz JA, Cruz M, Lopez-Nevot MA, Galan JJ, Real LM, de Castro F, Lopez-Villaverde V, Ruiz A. Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis. J Exp Clin Assist Reprod. 2005 Aug 30;2:11. PMID: 16131398
40. De Castro F, Moron FJ, Montoro L, Galan JJ, Real LM, Ruiz A. Re: Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst. 2005 Jan 19;97(2):152-3; author reply 153-4. No abstract available. PMID: 15657347
41. Buch B, Galan JJ, Lara M, Real LM, Martinez-Moya M, Ruiz A. Absence of de novo Y-chromosome microdeletions in male children conceived through intracytoplasmic sperm injection. Fertil Steril. 2004 Dec;82(6):1679-80. PMID: 15589879
42. Fernandez ML, Ruiz R, Gonzalez MA, Ramirez-Lorca R, Couto C, Ramos A, Gutierrez-Tous R, Rivera JM, Ruiz A, Real LM, Grilo A. Association of NOS3 gene with metabolic syndrome in hypertensive patients. Thromb Haemost. 2004 Aug;92(2):413-8. PMID: 15269839
44. de Castro F, Moron FJ, Montoro L, Galan JJ, Hernandez DP, Padilla ES, Ramirez-Lorca R, Real LM, Ruiz A. Human controlled ovarian hyperstimulation outcome is a polygenic trait. Pharmacogenetics. 2004 May;14(5):285-93. PMID: 15115914
45. Manes S, Mira E, Colomer R, Montero S, Real LM, Gomez-Mouton C, Jimenez-Baranda S, Garzon A, Lacalle RA, Harshman K, Ruiz A, Martinez-A C. CCR5 expression influences the progression of human breast cancer in a p53-dependent manner. J Exp Med. 2003 Nov 3;198(9):1381-9. PMID: 14597737
46. Gonzalez A, Abril E, Roca A, Aragon MJ, Figueroa MJ, Velarde P, Ruiz R, Fayez O, Galan JJ, Herreros JA, Real LM, Ruiz A. Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients. J Clin Endocrinol Metab. 2003 Nov;88(11):5529-36. PMID: 14602801
47. Buch B, Galan JJ, Lara M, Ruiz R, Segura C, Real LM, Martinez-Moya M, Ruiz A.Scanning of Y-chromosome azoospermia factors loci using real-time polymerase chain reaction and melting curve analysis. Fertil Steril. 2003 Oct;80(4):907-13. PMID: 14556811
48. de Castro F, Ruiz R, Montoro L, Perez-Hernandez D, Sanchez-Casas Padilla E, Real LM, Ruiz A. Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone. Fertil Steril. 2003 Sep;80(3):571-6. PMID: 12969700
49. Gonzalez-Gomez F, Vergara F, Fernandez A, Pedrosa C, Ramirez JP, Castilla JA, Ruiz R, Galan JJ, Ruiz A, Real LM. Detection of pvull polymorphism within intron 1 of ESR1 gene by real-time PCR. Clin Chem Lab Med. 2003 Mar;41(3):392-3. No abstract available. PMID: 12705350
50. Gonzalez A, Abril E, Roca A, Aragon MJ, Figueroa MJ, Velarde P, Royo JL, Real LM, Ruiz A. Comment: CAPN10 alleles are associated with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Aug;87(8):3971-6. PMID: 12161543